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Objective To explore the impact of the personal rehabilitation treatment on life quality and curative offect of the schizophrenia patients.Methods A total of 84 patients with chronic schizophrenia in Shanxi Rongjun Corelle Hospital from December 2016 January 2018 were randomly divided into intervention group and control group on the basis of random number table,the two groups received psychiatric routine therapy nursing and general entertainment therapy,and the intervention group received 8 weeks of individualized rehabilitation therapy on this basis.The Schizophrenics Quality of Life Scale (SQLS) and Positive and Negative Symptoms Scale (PANSS) were respectively used to evaluate the effect of the two groups before and after intervention.Results After 8 weeks of systematic social skills training,the scores of negative symptoms,general psychopathology and total PANSS score in the intervention group were (14.65 ± 3.68) points,(24.21 ± 3.23) points,(52.83 ± 7.12) points,respectively,which in the control group were (21.82 ± 4.25) points,(28.08 ± 4.56) points,(60.67 ± 9.52) points,respectively,the differences between the two groups were statistically significant(t =5.18,3.35,3.92,all P ＜0.01),while the positive symptom score had no statistically significant difference between the two gorups (P ＞ 0.05).The PANSS scores and total score in the intervention group after intervention had statistically significant differences compared with those before intervention (t =2.17,5.98,3.86,4.13,all P ＜ 0.05).After the intervention training,the psychosocial score,motivation and energy score,symptoms and adverse reactions score,and total score of SQLS in the intervention group were (32.64 ±7.32)points,(39.45 ± 10.87) points,(18.16 ± 10.48) points,(90.34 ± 24.17) points,which in the control group were (35.32 ±10.64) points,(43.82 ± 12.43) points,(21.05 ± 11.52) points,(98.25 ± 32.29) points,respectively,and the differences between the two groups were statistically significant (t =2.46,3.51,3.12,3.96,all P ＜ 0.05).The SQLS scores and total score in the intervention group after intervention had statistically significant differences compared with those before intervention (t =3.94,4.72,3.87,5.01,all P ＜ 0.01).Conclusion The personal rehabilitationtreatment can greatly promote the curative offect of patients with chronic schizophrenia,improve their life qualities.
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Objective@#To explore the impact of the personal rehabilitation treatment on life quality and curative offect of the schizophrenia patients.@*Methods@#A total of 84 patients with chronic schizophrenia in Shanxi Rongjun Corelle Hospital from December 2016 January 2018 were randomly divided into intervention group and control group on the basis of random number table, the two groups received psychiatric routine therapy nursing and general entertainment therapy, and the intervention group received 8 weeks of individualized rehabilitation therapy on this basis.The Schizophrenics Quality of Life Scale(SQLS) and Positive and Negative Symptoms Scale(PANSS) were respectively used to evaluate the effect of the two groups before and after intervention.@*Results@#After 8 weeks of systematic social skills training, the scores of negative symptoms, general psychopathology and total PANSS score in the intervention group were (14.65±3.68)points, (24.21±3.23)points, (52.83±7.12)points, respectively, which in the control group were (21.82±4.25)points, (28.08±4.56)points, (60.67±9.52)points, respectively, the differences between the two groups were statistically significant(t=5.18, 3.35, 3.92, all P<0.01), while the positive symptom score had no statistically significant difference between the two gorups (P>0.05). The PANSS scores and total score in the intervention group after intervention had statistically significant differences compared with those before intervention (t=2.17, 5.98, 3.86, 4.13, all P<0.05). After the intervention training, the psychosocial score, motivation and energy score, symptoms and adverse reactions score, and total score of SQLS in the intervention group were (32.64±7.32)points, (39.45±10.87)points, (18.16±10.48)points, (90.34±24.17)points, which in the control group were (35.32±10.64)points, (43.82±12.43)points, (21.05±11.52)points, (98.25±32.29)points, respectively, and the differences between the two groups were statistically significant (t=2.46, 3.51, 3.12, 3.96, all P<0.05). The SQLS scores and total score in the intervention group after intervention had statistically significant differences compared with those before intervention(t=3.94, 4.72, 3.87, 5.01, all P<0.01).@*Conclusion@#The personal rehabilitation treatment can greatly promote the curative offect of patients with chronic schizophrenia, improve their life qualities.
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Objective Polyinosinic-polycytidylic acid (poly IC) plays an important role in the central nervous system damage and repair.This study was to investigate the effect of poly IC on inflammatory response after spinal cord ischemia-reperfusion injury (SCIRI) in rats.Methods A total of 72 healthy adult male SD rats were equally randomized into a sham-operation, an ischemia-reperfusion (IR), and a poly IC group.The abdominal cavities of the rats were cut open and closed again in the sham-operation group and SCIRI models were established in the IR and poly IC groups by clamping the abdominal aorta, followed by reperfusion 60 minutes later and intraperitoneal injection of saline (0.1 mL) and poly IC (1.25 μg/g), respectively.At 6, 24, and 48 hours after modeling, BBB scores were obtained and the contents of TNFα, IL-1β and IFN-β were measured by ELISA.At 48 hours, the expressions of NF-κB and IL-10 were determined by immunohistochemistry, the area of ischemic necrosis in the spinal cord tissue was calculated by TTC staining, and its morphological changes were observed under the optical microscope.Results At 48 hours after modeling, the BBB scores were significantly lower in the IR and poly IC groups than in the sham-operation group (3.80±0.75 and 9.40±0.49 vs 20.00±0.00, P<0.01), though higher in the poly IC than in the IR group (P<0.01).The rats of the IR group showed extensive degenerated neurons in the gray substance of the spinal cord, with scattered foci of bleeding and blood coagulation, while those of the poly IC group exhibited fewer necrotic neurons and basically normal nuclear morphology, though with a few swelling cells.The ischemic necrosis area of the spinal cord tissue was significantly reduced.The expression of NF-κB was decreased while that of IL-10 increased markedly.Compared with the IR group, the poly IC group showed a significant increase in the expression of IFNβ (117.23±6.06 vs 55.65±4.02, P<0.01) and a remarkably decrease in the expressions of TNFα (190.45±4.16 vs 201.82±2.18, P<0.01) and IL-1β (39.27±2.48 vs 50.59±1.47, P<0.01) at 48 hours.Conclusion Poly IC can protect the spinal cord and reduce inflammatory response after spinal cord ischemia-reperfusion injury.
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han that in the control one (t=3.94, P<0.01).Conclusion Social skills training can effectively improve subjective satisfactions of the long-terra hospitalized patients with chronic schizophrenia.
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OBJECTIVE To discuss the risk factors causing nosocomial infection in department of psychiatry,Hospital for Mental Health and Rehabilitation so that to provide basis for prevention and control of nosocomial infections.METHODS Both the prospective and retrospective investigations were carried out among 3 525 inpatients form Jan 1,2006 to Dec 31,2006.RESULTS Eighty-five cases of nosocomial infection were with infection rate of 2.41%.The upper respiratory tract infection,gastrointestinal infection and lower respiratory tract infection were the top 3 infections.CONCLUSIONS The occurrence of nosocomial infection is related to the susceptibility,hospital stay time,unreasonable drug application,managing model of mental health hospital and antipsychotics usage.
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OBJECTIVE To understand the antibacterial medicine usage in inpatients in department of psychiatry to promote the rational use of antibacterial drugs. METHODS Totally 4092 cases of inpatients from Jan 1 to Dec 31 2007 were studied.Both the prospective monitoring and retrospective investigation were carried out. RESULTS From them 471 cases were administrated with antibacterial drugs,and the usage rate was 11.51%,among which the therapeutic administration accounted for 58.17%,and the preventive one of 41.61%(P